Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers

被引：163

作者：

Yuan, Jiao ^{[1
,2
]}

Hu, Zhongyi ^{[1
,2
]}

Mahal, Brandon A. ^{[3
]}

Zhao, Sihai D. ^{[4
]}

Kensler, Kevin H. ^{[5
,6
]}

Pi, Jingjiang ^{[7
]}

Hu, Xiaowen ^{[1
,2
]}

Zhang, Youyou ^{[1
,2
]}

Wang, Yueying ^{[1
,2
]}

Jiang, Junjie ^{[1
,2
]}

Li, Chunsheng ^{[1
,2
]}

Zhong, Xiaomin ^{[8
]}

Montone, Kathleen T. ^{[9
]}

Guan, Guoqiang ^{[10
]}

Tanyi, Janos L. ^{[2
]}

Fan, Yi ^{[11
]}

Xu, Xiaowei ^{[9
]}

Morgan, Mark A. ^{[2
]}

Long, Meixiao ^{[12
]}

Zhang, Yuzhen ^{[7
]}

Zhang, Rugang ^{[13
]}

Sood, Anil K. ^{[14
,15
]}

Rebbeck, Timothy R. ^{[5
,6
]}

Dang, Chi V. ^{[13
,16
]}

Zhang, Lin ^{[1
,2
]}

机构：

[1] Univ Penn, Ctr Res Reprod & Womens Hlth, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA

[3] Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02215 USA

[4] Univ Illinois, Dept Stat, Champaign, IL 61801 USA

[5] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[6] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[7] Tongji Univ, Sch Med, Shanghai East Hosp, Res Ctr Translat Med, Shanghai 200120, Peoples R China

[8] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Biol, Ctr Stem Cell Biol & Tissue Engn, Guangzhou 510080, Guangdong, Peoples R China

[9] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[10] Univ Penn, Dept Orthodont, Philadelphia, PA 19104 USA

[11] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA

[12] Ohio State Univ, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

[13] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA

[14] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNA, Houston, TX 77030 USA

[15] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX 77584 USA

[16] Ludwig Inst Canc Res, New York, NY 10017 USA

来源：

CANCER CELL | 2018年 / 34卷 / 04期

关键词：

AFRICAN-AMERICANS; MUTATIONAL PROCESSES; PROSTATE-CANCER; BREAST-CANCER; LANDSCAPE; OPPORTUNITIES; EPIDEMIOLOGY; ASSOCIATION; DISPARITIES; STATISTICS;

D O I：

10.1016/j.ccell.2018.08.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Disparities in cancer care have been a long-standing challenge. We estimated the genetic ancestry of The Cancer Genome Atlas patients, and performed a pan-cancer analysis on the influence of genetic ancestry on genomic alterations. Compared with European Americans, African Americans (AA) with breast, head and neck, and endometrial cancers exhibit a higher level of chromosomal instability, while a lower level of chromosomal instability was observed in AAs with kidney cancers. The frequencies of TP53 mutations and amplification of CCNE1 were increased in AAs in the cancer types showing higher levels of chromosomal instability. We observed lower frequencies of genomic alterations affecting genes in the PI3K pathway in AA patients across cancers. Our result provides insight into genomic contribution to cancer disparities.

引用

页码：549 / +

页数：21

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