Importance of CD4+ helper T-cells in antitumor immunity

被引：47

作者：

Shiku, H ^{[1
]}

机构：

[1] Mie Univ, Sch Med, Dept Internal Med 2, Tsu, Mie, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2003年 / 77卷 / 05期

关键词：

tumor antigen; peptide; CTL; helper T-cells; MHC;

D O I：

10.1007/BF02986610

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CD8(+) cytotoxic T-lymphocytes are major effector cells involved in immunologically specific tumor destruction in vivo, and CD4(+) T-cells are essential for controlling this CD8(+) T-cell-dependent tumor eradication. The presence of CD4(+) T-cells with distinct functional roles has been recognized. The further understanding of the complexity of antitumor immune responses by CD4(+) T-cells may be crucial for designing more effective cancer vaccines. (C) 2003 The Japanese Society of Hematology.

引用

页码：435 / 438

页数：4

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