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- [4] Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3′5′-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromogranin A promoter MOLECULAR ENDOCRINOLOGY, 2002, 16 (12) : 2802 - 2818