SAFETY AND PHARMACOKINETICS OF ABI-H3733, A NOVEL 2nd GENERATION HBV CORE PROTEIN INHIBITOR: RESULTS FROM A PHASE 1a STUDY IN HEALTHY VOLUNTEERS

被引:0
|
作者
Gane, Edward J. [1 ]
Schwabe, Christian [2 ]
Alves, Katia [3 ]
Evanchik, Marc [3 ]
Ma, Julie [3 ]
Zomorodi, Katie [3 ]
Knox, Steven J. [3 ]
Stamm, Luisa M. [3 ]
机构
[1] Auckland City Hosp, Liver Transplant Unit, Auckland, New Zealand
[2] New Zealand Clin Res, Auckland, New Zealand
[3] Assembly Biosci Inc, San Francisco, CA USA
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D O I
暂无
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R57 [消化系及腹部疾病];
学科分类号
摘要
842
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页码:516A / 516A
页数:1
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  • [1] Phase 1a Study of the Safety, Tolerability and Pharmacokinetics of ABI-H2158, a Novel Second-Generation HBV Core Inhibitor, in Healthy Volunteers
    Gane, Edward
    Schwabe, Christian
    Evanhcik, Marc
    Ruby, Eric
    Liaw, Sandy
    Alves, Katia
    Colonno, Richard
    Lopatin, Uri
    [J]. JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E146 - E147
  • [2] Preclinical profile of HBV core protein inhibitor, ABI-H3733, a potent inhibitor of cccDNA generation in HBV infected cells
    Huang, Qi
    Haydar, Simon
    Zhou, Yi
    Cai, Dawei
    Xu, Xiang
    Yan, Ran
    Guo, Lida
    Carabajal, Esteban
    Tang, Xuman
    Walker, Michael
    Rai, Roopa
    Bures, Mark
    Li, Leping
    Colonno, Richard
    [J]. JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E48 - E48
  • [3] The safety and pharmacokinetics of ABI-4334, a novel next-generation HBV core inhibitor: interim results from a phase 1 study in healthy volunteers
    Gane, Edward J.
    Schwabe, Christian
    Liu, Jieming
    Stamm, Luisa M.
    Kitrinos, Kathryn M.
    Knox, Steven J.
    Anderson, Michele
    Wang, Grace
    Zomorodi, Katie
    [J]. JOURNAL OF HEPATOLOGY, 2023, 78 : S1161 - S1162
  • [4] Phase 1a Safety and Pharmacokinetics (PK) of ABI-H0731, a Novel Core Protein Allosteric Modifier (CpAM) For The Treatment of Chronic HBV Infection
    Gane, Edward J.
    Schwabe, Christian
    Liaw, Sandy
    Ruby, Eric
    Li, Leping
    Chan, Kelvin
    Patel, Kashyap
    Smith, Patrick
    Colonno, Richard
    Lopatin, Uri A.
    [J]. HEPATOLOGY, 2017, 66 : 495A - 495A
  • [5] Safety, pharmacokinetics, and antiviral activity of the next-generation hepatitis B core inhibitor ABI-H3733 in patients with hepatitis B e antigen negative chronic hepatitis B infection: preliminary results from a randomized, blinded, Phase 1b study
    Gane, Edward J.
    Jucov, Alina
    Katzarov, Krum
    Sandulescu, Oana
    Yan, Ran
    Kitrinos, Kathryn M.
    Liu, Jieming
    Zomorodi, Katie
    Stamm, Luisa M.
    Knox, Steven J.
    Anderson, Michele
    Wang, Grace
    Tsrancheva, Radoslava
    Streinu-Cercel, Anca
    [J]. JOURNAL OF HEPATOLOGY, 2023, 78 : S1149 - S1150
  • [6] PHARMACOKINETICS, SAFETY AND TOLERANCE OF BCD-085, A NOVEL IL-17 INHIBITOR, BASED ON THE RESULTS OF PHASE 1 CLINICAL STUDY IN HEALTHY VOLUNTEERS
    Chernyaeva, E.
    Eremeeva, A.
    Galustyan, A.
    Ivanov, R.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 : 429 - 429
  • [7] A PHASE 1 STUDY IN HEALTHY VOLUNTEERS EXPLORING THE SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS OF ATI-450: A NOVEL ORAL MK2 INHIBITOR
    Schnyder, J.
    Monahan, J.
    Smith, W.
    Hope, H.
    Kelly, D.
    Burt, D.
    Huff, E.
    Kaul, A.
    Hildebrand, A.
    Burnette, B.
    Klug, N.
    Bangs, M.
    Gordon, D.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 1006 - 1006
  • [8] Pharmacokinetics, Safety, and Tolerability of Etrasimod: Results From a Phase 1 Drug-Drug Interaction Study in Healthy Volunteers
    Lee, Caroline A.
    Tang, Yong
    Villa-Caballero, Leonel
    Shan, Kevin
    Randle, Andrenika
    Grundy, John S.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2022, 117 (10): : S550 - S550
  • [9] Safety, pharmacokinetics and antiviral activity of ABI-H2158, a hepatitis B virus core inhibitor: A randomized, placebo-controlled phase 1 study
    Agarwal, Kosh
    Xu, Jia
    Gane, Edward J.
    Nguyen, Tuan T.
    Ding, Yanhua
    Knox, Steven J.
    Alves, Katia
    Evanchik, Marc
    Zomorodi, Katie
    Ma, Julie
    Yan, Ran
    Huang, Qi
    Colonno, Richard
    Stamm, Luisa M.
    Hassanein, Tarek I.
    Kim, Dong Joon
    Lim, Young-Suk
    Yuen, Man-Fung
    [J]. JOURNAL OF VIRAL HEPATITIS, 2023, 30 (03) : 209 - 222
  • [10] Pharmacokinetics, pharmacodynamics and safety of BAY 2433334, a novel activated factor XI inhibitor, in healthy volunteers: A randomized phase 1 multiple-dose study
    Kubitza, Dagmar
    Heckmann, Michael
    Distler, Jana
    Koechel, Annemone
    Schwers, Stephan
    Kanefendt, Friederike
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2022, 88 (07) : 3447 - 3462