Concise Review: Stem Cells As an Emerging Platform for Antibody Therapy of Cancer

被引：26
|
作者：
Frank, Richard T. [1 ,3 ,4 ]
Najbauer, Joseph [1 ]
Aboody, Karen S. [1 ,2 ,4 ]
机构：
[1] City Hope Natl Med Ctr, Dept Neurosci, Duarte, CA 91010 USA
[2] City Hope Natl Med Ctr, Div Neurosurg, Duarte, CA 91010 USA
[3] City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, Duarte, CA 91010 USA
[4] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA
来源：
STEM CELLS | 2010年 / 28卷 / 11期
关键词：
Antibody; Blood-brain barrier; Cancer therapy; alpha-Carcinoembryonic antigen; CD3; Diabody; EGFR; HER2; Neural stem cells; Mesenchymal stem cells; scFv; CLASS-I; GLIOMA; LYMPHOCYTES; EXPRESSION; SURVIVAL; HYPOXIA;
D O I：
10.1002/stem.513
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Monoclonal antibodies are important tools for cancer therapy, however, three factors limit their effectiveness: toxicity, poor tumor penetration, and inability to cross the blood-brain barrier. This review discusses the emerging field of stem cell-mediated antibody delivery and how this approach may improve antibody therapy of cancer by overcoming these obstacles. STEM CELLS 2010;28:2084-2087
引用
收藏
页码：2084 / 2087
页数：4
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