High frequency repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex in schizophrenic patients

被引:96
|
作者
Rollnik, JD [1 ]
Huber, TJ
Mogk, H
Siggelkow, S
Kropp, S
Dengler, R
Emrich, HM
Schneider, U
机构
[1] Hannover Med Sch, Dept Neurol & Clin Neurophysiol, D-30623 Hannover, Germany
[2] Hannover Med Sch, Dept Clin Psychiat & Psychotherapy, D-30623 Hannover, Germany
关键词
repetitive transcranial magnetic stimulation; schizophrenia; treatment;
D O I
10.1097/00001756-200012180-00022
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Repetitive transcranial magnetic stimulation (rTMS) has been tried therapeutically in major depression. In order to investigate the therapeutic efficacy of rTMS in psychotic patients, 12 participants (four women, eight men) with schizophrenia according to DSM-IV criteria, aged 25 to 63 years (mean (+/-s.d) 40.4 +/- 11.0), were enrolled in the study. Following a double-blind crossover design, patients were treated at random with 2 weeks of daily left prefrontal rTMS (20 2 s 20 Hz stimulations at 80% motor threshold over 20 min, dorsolateral preforntal cortex) and 2 weeks of sham stimulation. The Brief Psychiatric Rating Scale decreased under active rTMS (p < 0.05), whereas depressive symptoms (BDI) and anxiety (STAI) did not change significantly. Prefrontal rTMS might be effective in the non-pharmacological treatment of psychotic patients. NeuroReport 11:4013-4015 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码:4013 / 4015
页数:3
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