A Synthetic Peptide Derived from NK-Lysin with Activity Against Mycobacterium tuberculosis and its Structure-Function Relationship

被引：3

作者：

Gu Hao ^{[2
]}

Dai Rongji ^{[2
]}

Qiu Kui ^{[1
]}

Teng Zhongqiu ^{[2
]}

Wang Heyao ^{[1
]}

机构：

[1] Beijing Chao Yang Hosp, Dept Pharm, Beijing 100020, Peoples R China

[2] Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS | 2011年 / 17卷 / 04期

关键词：

NK-lysin; Mycobacterium tuberculosis; Antimycobacterial activity; Active fragments; ANTIMICROBIAL PEPTIDES; MOLECULAR-BASIS; HOST-DEFENSE; T-CELLS; GRANULYSIN; COMMON;

D O I：

10.1007/s10989-011-9268-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As appearance of drug resistant and multidrug resistant strains of Mycobacterium tuberculosis, antibiotics were no longer the only way to inhibit M. tuberculosis. It was shown that the porcine peptide NK-lysin is active against various microbes by interacting with microbial membranes. The NK-lysin-derived peptide has been demonstrated to possess stronger effect. Under this motivation, we synthesized a short peptide (N22) derived from an active fragment of NK-lysin-an important antimycobaterial domain involving the loop and the alpha-helical structure. Furthermore, we studied its stability and biological activity in vitro. The results showed that it inhibited the growth of M. tuberculosis H37Rv and had a low toxicity to human erythrocyte.

引用

页码：301 / 306

页数：6

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