Forward genetic dissection of innate response to infection in inbred mouse strains: selected success stories

被引：16
|
作者：
Gruenheid, S. [1 ,2 ]
Gros, P. [1 ,3 ]
机构：
[1] McGill Univ, Complex Traits Program, Montreal, PQ H3G 0B1, Canada
[2] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3G 0B1, Canada
[3] McGill Univ, Dept Biochem, Montreal, PQ H3G 0B1, Canada
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2010年 / 162卷 / 03期
关键词：
host resistance; infection; innate immunity; mouse genetics; MAJOR HISTOCOMPATIBILITY COMPLEX; HOST-RESISTANCE LOCUS; ANTHRAX LETHAL TOXIN; NOD-LIKE RECEPTORS; NK CELL RECEPTORS; NATURAL-RESISTANCE; LEGIONELLA-PNEUMOPHILA; INFLUENZA-VIRUS; CHLAMYDIA-TRACHOMATIS; 2'; 5'-OLIGOADENYLATE SYNTHETASE;
D O I：
10.1111/j.1365-2249.2010.04249.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P>Mouse genetics is a powerful tool for the dissection of genes, proteins, and pathways important in biological processes. Application of this approach to study the host response to infection has been a rich source of discoveries that have increased our understanding of the early innate pathways involved in responding to microbial infections. Here we review some of the key discoveries that have arisen from pinpointing the genetic defect in mouse strains with unusual or extreme response to infection and have led to insights into pathogen sensing pathways and downstream effector functions of the early innate immune response.
引用
收藏
页码：393 / 401
页数：9
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