Leflunomide for the treatment of trichodysplasia spinulosa in a liver transplant recipient

被引：17

作者：

Kassar, Rawan ^{[1
,2
]}

Chang, Janis ^{[1
,2
]}

Chan, An-Wen ^{[2
,3
]}

Lilly, Leslie B. ^{[4
]}

Al Habeeb, Ayman ^{[5
]}

Rotstein, Coleman ^{[1
,2
]}

机构：

[1] Univ Toronto, Div Infect Dis, Dept Med, Toronto, ON, Canada

[2] Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON, Canada

[3] Univ Toronto, Univ Hlth Network, Div Dermatol, Dept Med, Toronto, ON, Canada

[4] Toronto Gen Hosp, Univ Hlth Network, Liver Transplant Program, Toronto, ON, Canada

[5] Univ Hlth Network, Dept Pathol, Toronto, ON, Canada

来源：

TRANSPLANT INFECTIOUS DISEASE | 2017年 / 19卷 / 04期

关键词：

complications; dermatologic complication; immunosuppressive regimens; infection and infectious agents; infectious; leflunomide; minimization/withdrawal; trichodysplasia spinulosa; trichodysplasia spinulosa-associated polyomavirus; viral; VIRAL-ASSOCIATED TRICHODYSPLASIA; ORAL-VALGANCICLOVIR; HUMAN POLYOMAVIRUS; PATIENT; INHIBITION; INFECTION;

D O I：

10.1111/tid.12702

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Trichodysplasia spinulosa (TS) is a rare dermatologic complication associated with the immunosuppressive therapy used in solid organ transplantation. The distinctive clinical manifestation of this condition is spiny follicular papules on the face, ears, extremities, and trunk. Histopathologically, abnormally maturing hair follicles with hyperkeratotic material are noted. The condition is produced by the trichodysplasia spinulosa-associated polyomavirus. Treatment of this condition in the past has entailed a reduction in immunosuppression, topical agents such as cidofovir or retinoids, or oral valganciclovir. Herein, we report a case of generalized TS treated successfully with leflunomide.

引用

页数：4

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