An explicit formula for minimizing the infected peak in an SIR epidemic model when using a fixed number of complete lockdowns

被引:11
|
作者
Sontag, Eduardo D. [1 ,2 ,3 ]
机构
[1] Northeastern Univ, Dept Elect & Comp Engn & Bioengn, Boston, MA 02115 USA
[2] Northeastern Univ, Dept Math, Boston, MA 02115 USA
[3] Harvard Med Sch, Lab Syst Pharmacol, Boston, MA 02115 USA
基金
美国国家科学基金会;
关键词
COVID-19; epidemics; lockdowns; mathematical epidemiology; SIR model;
D O I
10.1002/rnc.5701
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
Careful timing of nonpharmaceutical interventions such as social distancing may avoid high "second waves" of infections of COVID-19. This article asks what should be the timing of a set of K complete-lockdowns of prespecified lengths (such as two weeks) so as to minimize the peak of the infective compartment. Perhaps surprisingly, it is possible to give an explicit and easily computable rule for when each lockdown should commence. Simulations are used to show that the rule remains fairly accurate even if lockdowns are not perfect.
引用
收藏
页码:4708 / 4731
页数:24
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