DNA photodamage recognition by RNA polymerase II

被引：19
|
作者：
Brueckner, Florian
Cramer, Patrick
机构：
[1] Univ Munich, Dept Chem & Biochem, Gene Ctr Munich, D-81377 Munich, Germany
[2] Univ Munich, Dept Chem & Biochem, Ctr Integrated Protein Sci, D-81377 Munich, Germany
来源：
FEBS LETTERS | 2007年 / 581卷 / 15期
关键词：
transcription-coupled DNA repair; multisubunit cellular RNA polymerases; structural biology of gene transcription;
D O I：
10.1016/j.febslet.2007.05.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure-function analysis of Pol II transcribing DNA with a bulky photo-lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription-coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2757 / 2760
页数：4
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