Enantioselective Reformatsky Reaction of Ketones Catalyzed by Chiral Indolinylmethanol

被引：5

作者：

Luo, Renshi ^{[1
,2
]}

Chen, Miao-Miao ^{[1
]}

Ouyang, Lu ^{[2
]}

Chan, Albert S. C. ^{[1
]}

Lu, Gui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Dept Guangdong Prov Key Lab Chiral Mol & Drug Dis, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Jiangxi, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 30期

基金：

中国国家自然科学基金;

关键词：

ALDEHYDES; IODOACETATE; ETHERS; ME2ZN; POT;

D O I：

10.1002/ejoc.202000768

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A reliable and practical Reformatsky reaction of ethyl iodide acetate with ketones for the synthesis of chiral beta-hydroxyl carbonyl compounds in good yields and excellent enantioselectivities is presented. A readily available dihydroindole derivative was used as chiral catalyst, ethyl iodide acet- ate was the nucleophile, and Me2Zn was the zinc source. The presence of air was found to be essential for the efficient construction of new carbon-carbon bonds through a radical pathway.

引用

页码：4805 / 4811

页数：7

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