Closed-loop all-optical interrogation of neural circuits in vivo

被引：112
|
作者：
Zhang, Zihui [1 ,2 ]
Russell, Lloyd E. [1 ]
Packer, Adam M. [1 ,3 ]
Gauld, Oliver M. [1 ]
Hausser, Michael [1 ]
机构：
[1] UCL, Wolfson Inst Biomed Res, London, England
[2] UCL, Dept Elect & Elect Engn, London, England
[3] Univ Oxford, Oxford, England
来源：
NATURE METHODS | 2018年 / 15卷 / 12期
基金：
英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
2-PHOTON EXCITATION; OPTOGENETIC CONTROL; NEURONS; PHOTOSTIMULATION; RECORDINGS; IMAGE;
D O I：
10.1038/s41592-018-0183-z
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity 'on the fly' during behavior.
引用
收藏
页码：1037 / +
页数：9
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