Motixafortide (BL-8040) and G-CSF Versus Placebo and G-CSF to Mobilize Hematopoietic Stem Cells for Autologous Stem Cell Transplantation in Patients with Multiple Myeloma: The Genesis Trial

被引：4

作者：

Crees, Zachary D. ^{[1
]}

Stockerl-Goldstein, Keith E. ^{[2
]}

Larson, Sarah ^{[3
]}

Illes, Arpád ^{[4
]}

Milone, Giuseppe ^{[5
]}

Martino, Massimo ^{[6
]}

Stiff, Patrick ^{[7
]}

Sborov, Douglas W. ^{[8
]}

Pereira, Denise L. ^{[9
]}

Micallef, Ivana N. ^{[10
]}

Jimenez, Gemma Moreno ^{[11
]}

Mikala, Gabor ^{[12
]}

Coronel, Maria liz paciello ^{[13
]}

Holtick, Udo ^{[14
]}

Hiemenz, John W. ^{[15
]}

Qazilbash, Muzaffar H. ^{[16
]}

Hardy, Nancy M. ^{[17
]}

Latif, Tahir ^{[18
]}

Garcia-Cadenas, Irene ^{[19
]}

Vainstein, Abi ^{[20
]}

Sorani, Ella ^{[20
]}

Gliko-Kabir, Irit ^{[20
]}

Goldstein, Inbal ^{[20
]}

Kadosh, Shaul

DiPersio, John F. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Div Oncol, St Louis, MO USA

[2] Washington Univ, Sch Med, Dept Med, BMT & Leukemia Program, St Louis, MO USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA

[4] Univ Debrecen, Fac Med, Dept Hematol, Debrecen, Hungary

[5] Azienda Policlin Vittorio Emanuele, Hematol & BMT Unit, Catania, Italy

[6] BMM Hosp, Stem Cell Transplant & Cellular Therapies Unit, Reggio Di Calabria, Italy

[7] Loyola Univ Med Ctr, Maywood, IL 60153 USA

[8] Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT USA

[9] Univ Miami, Sylvester Canc Ctr, Miami, FL USA

[10] Mayo Clin, Div Hematol, Rochester, MN USA

[11] Hosp Ramon & Cajal, Dept Hematol, Madrid, Spain

[12] Ctr Hosp Southern Pest, Budapest, Hungary

[13] Hosp Univ 12 Octubre, Madrid, Spain

[14] Univ Hosp Cologne, Dept Internal Med 1, Leukapheresis & Stem Cell Transplant Unit, Cologne, Germany

[15] Univ Florida, Dept Med, Div Hematol Oncol, Gainesville, FL USA

[16] MD Anderson Canc Ctr, Houston, TX USA

[17] Univ Maryland, Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA

[18] Univ Cincinatti, Coll Med, Cincinnati, OH USA

[19] Hosp Santa Creu & Sant Pau, Dept Hematol, Barcelona, Spain

[20] BiolineRx Ltd, ModiIn, Israel

来源：

BLOOD | 2021年 / 138卷

关键词：

D O I：

10.1182/blood-2021-144296

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

475

引用

页数：7

共 50 条

[1] Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma
DiPersio, John F.
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Stiff, Patrick J.
Kaufman, Jonathan L.
Maziarz, Richard T.
Hosing, Chitra
Frueehauf, Stefan
Horwitz, Mitchell
Cooper, Dennis
Bridger, Gary
Calandra, Gary
[J]. BLOOD, 2009, 113 (23) : 5720 - 5726
[2] Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a randomized phase 3 trial
Zachary D. Crees
Michael P. Rettig
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Keith Stockerl-Goldstein
Sarah M. Larson
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Massimo Martino
Patrick Stiff
Douglas Sborov
Denise Pereira
Ivana Micallef
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[J]. Nature Medicine, 2023, 29 : 869 - 879
[3] Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a randomized phase 3 trial
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[J]. NATURE MEDICINE, 2023, 29 (4) : 869 - 879
[4] Immunophenotypic and Single-Cell Transcriptional Profiling of CD34+Hematopoietic Stem and Progenitor Cells Mobilized with Motixafortide (BL-8040) and G-CSF Versus Plerixafor and G-CSF Versus Placebo and G-CSF: A Correlative Study of the Genesis Trial
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[J]. BLOOD, 2021, 138 : 3816 - +
[5] Plerixafor and G-CSF Versus Cyclophosphamide and G-CSF for Stem Cell Mobilization in Patients with Multiple Myeloma
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[J]. BLOOD, 2009, 114 (22) : 844 - 844
[6] Pegylated G-CSF after autologous hematopoietic stem cell transplantation
Annaloro, C.
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Onida, F.
Basilico, C.
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[J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 74 - 74
[7] Outcomes of G-CSF alone vs G-CSF with upfront plerixafor vs G-CSF/chemotherapy for collection of autologous stem cells in patients with multiple myeloma.
Talamo, Giampaolo
George, Melissa
Ehmann, W. Christopher
Drabick, Joseph J.
Mineishi, Shin
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
[8] GENESIS: Phase III trial evaluating BL-8040+G-CSF to mobilize hematopoietic cells for autologous transplant in myeloma
Crees, Zachary D.
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[J]. FUTURE ONCOLOGY, 2019, 15 (31) : 3555 - 3563
[9] Clinical outcomes of multiple myeloma patients who undergo autologous hematopoietic stem cell transplant with G-CSF or G-CSF and plerixafor mobilized grafts
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Uberti, Joseph
Deol, Abhinav
[J]. AMERICAN JOURNAL OF HEMATOLOGY, 2020, 95 (02) : 198 - 204
[10] Cyclophosphamide, etoposide and G-CSF to mobilize peripheral blood stem cells for autologous stem cell transplantation in patients with lymphoma
P Mollee
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R Saragosa
A Keating
M Crump
[J]. Bone Marrow Transplantation, 2002, 30 : 273 - 278

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