Evaluation of bone mineral density in premenopausal women with type-2 diabetes mellitus in Zahedan, southeast Iran

Objective: To determine the BMD in premenopausal women with type-2 diabetes mellitus. Methods: This case-control study was performed on 60 premenopausal women with type-2 diabetes mellitus and 60 normal premenopausal subjects. The groups were not completely matched regarding BMI; but they were in the range of obesity. Bone mineral density was determined using dual energy X-ray absorptiometry (DXA) to define bone mineral density (BMD) in second to fourth lumbar vertebrae and the neck of the femur (g/cm2). Results: The results showed that BMD, T- and Z-score of femoral neck, total femur, L2, and Ward's were not significantly different between type 2 diabetic and normal premenopausal women (p > 0.5). A significant increase of L3 BMD and L2-L4 Z-score was observed in diabetic group (p < 0.05). In addition BMD, T- and Z-score of L4 were significantly higher in type 2 diabetic women than normal premenopausal women (P < 0.05). Conclusion: Higher BMD was noted over the spine in diabetic group which may be due to higher BMI in this group.