The green-synthesized curcumin-mediated zinc oxide nanoparticles (CmZnO-NP) as the exclusive antioxidant and efficient wound healing agent compared with curcumin, methanol, phenytoin, and ZnO

被引：5

作者：

Dianati, Elahe ^{[1
]}

Hojati, Vida ^{[1
]}

Khayatzadeh, Jina ^{[1
,2
]}

Zafar Balanezhad, Saeedeh ^{[1
,2
]}

机构：

[1] Islamic Azad Univ, Damghan Branch, Dept Biol, Damghan, Iran

[2] Islamic Azad Univ, Mashhad Branch, Dept Biol, Mashhad 1696700, Razavi Khorasan, Iran

来源：

INORGANIC AND NANO-METAL CHEMISTRY | 2021年

关键词：

Curcumin-mediated ZnO nanoparticles; antioxidant; wound healing potential; OXIDATIVE STRESS; ANTIBACTERIAL; HYDROGELS; ADHESIVE;

D O I：

10.1080/24701556.2021.1956964

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Curcumin and Zinc oxide nanoparticle (ZnO-NP) are known as organic and mineral wound healing agents, respectively. In this study, we aimed to green-synthesize the curcumin-mediated ZnO-NP (CmZnO-NP) and evaluate biological properties. In this study, CmZnO-NP were synthesized and after characterizing (DLS, XRD, FT IR, FESEM) its antioxidant effects (ABTS, DPP H), toxicity (MTT) and wound healing (H&E staining and gene expression) were investigated. The 30.77-nm CmZnO-NP significantly scavenged both free radicals. Also, its wound healing activity was observed by detecting the meaningful reduction in the length and depth of the rat's skin wound. The collagen and VEGF up-regulation of the rat skin tissue following the increasing CmZnO-NP treatment doses confirmed its wound healing potential. Due to antioxidant and improved wound healing activities of the CmZnO-NP, it has the potential to be studied as an efficient wound healing compound.

引用

页数：10