Epitopes on β2-GPI recognized by anticardiolipin antibodies

被引：39
|
作者：
Koike, T
Ichikawa, K
Kasahara, H
Atsumi, T
Tsutsumi, A
Matsuura, E
机构：
[1] Hokkaido Univ, Sch Med, Dept Med 2, Kita Ku, Sapporo, Hokkaido 060, Japan
[2] Okayama Univ, Sch Med, Inst Mol & Cellular Biol, Dept Cell Chem, Okayama 700, Japan
来源：
LUPUS | 1998年 / 7卷
关键词：
anticardiolipin antibodies; beta 2-glycoprotein I; epitopes; structure of beta 2-GPI;
D O I：
10.1177/096120339800700204
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Anticardiolipin antibodies (aCL) found in sera from patients with antiphospholipid syndrome recognize a cryptic epitope that appears on the beta 2-glycoprotein I (beta 2-GPI) molecule when beta 2-GPI interacts with a lipid membrane composed of negatively charged phospholipid or when beta 2-GPI is adsorbed on a polyoxygenated polystyrene plate. A homology based model of beta 2-GPI was constructed based on the NMR coordinates of sushi domains of human factor H. The conformation was like a cylinder consisting of five domains, its IV and V domains being glued by electrostatic interaction. We used phage-displayed random peptide libraries to search the epitopes of human aCL. Structures similar to consensus sequences selected by a biopanning method was found on domain IV of beta 2-GPI.
引用
收藏
页码：S14 / S17
页数：4
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