Two novel trichothecenes from Myrothecium roridum

被引：9
|
作者：
Wang, Tao [1 ]
Zhang, Yi [1 ]
Pei, Yue-hu [2 ]
机构：
[1] Kyoto Pharmaceut Univ, Dept Pharmacognosy, Kyoto 60784129, Japan
[2] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110016, Peoples R China
来源：
MEDICINAL CHEMISTRY RESEARCH | 2007年 / 16卷 / 04期
关键词：
Isororidin P; Myrothecium roridum; Pyricularia oryzae; NMR; Roridin P;
D O I：
10.1007/s00044-007-9012-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new trichothecenes, Roridin P and Isororidin P, and two known trichothecenes, Verrucarin A and Verrucarin J, were isolated from liquid cultures of Myrothecium roridum Tale ex Fr. The stereo-structures of Roridin P and Isororidin P were established on the basis of one- and two-dimensional nuclear magnetic resonance (NMR) spectral analyses. Roridin P and Isororidin P induced morphological changes in Pyricularia oryzae, with a minimum concentration (MMCC) value of 6.2 +/- 1.1 mu mol/L and 7.9 +/- 1.5 mu mol/L.
引用
收藏
页码：155 / 161
页数：7
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