Small-animal SPECT and SPECT/CT: application in cardiovascular research

被引：36
|
作者：
Golestani, Reza [2 ]
Wu, Chao [2 ,5 ,6 ]
Tio, Rene A. [3 ,10 ]
Zeebregts, Clark J. [4 ,10 ]
Petrov, Artiom D. [7 ]
Beekman, Freek J. [5 ,6 ,8 ,9 ]
Dierckx, Rudi A. J. O. [2 ]
Boersma, Hendrikus H. [1 ,2 ,10 ]
Slart, Riemer H. J. A. [2 ,10 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Clin & Hosp Pharm, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, NL-9700 RB Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Ctr Thorax, NL-9700 RB Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Div Vasc Surg, Dept Surg, NL-9700 RB Groningen, Netherlands
[5] Univ Med Ctr Utrecht, Image Sci Inst, Groningen, Netherlands
[6] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands
[7] Univ Calif Irvine, Sch Med, Div Cardiol, Irvine, CA 92717 USA
[8] Delft Univ Technol, Sect Radiat Detect & Med Imaging, Fac Sci Appl, Delft, Netherlands
[9] MILabs, Utrecht, Netherlands
[10] Univ Groningen, Univ Med Ctr Groningen, Cardiovasc Imaging Grp, NL-9700 RB Groningen, Netherlands
来源：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2010年 / 37卷 / 09期
关键词：
microSPECT; microSPECT/CT; Cardiovascular imaging; ULTRA-HIGH-RESOLUTION; IN-VIVO DETECTION; COMPUTED TOMOGRAPHY/COMPUTED TOMOGRAPHY; ACUTE MYOCARDIAL-INFARCTION; PHOTON-EMISSION-TOMOGRAPHY; CARDIAC PERFUSION SPECT; PINHOLE GATED SPECT; HEART-FAILURE; MATRIX-METALLOPROTEINASE; CELL-DEATH;
D O I：
10.1007/s00259-009-1321-8
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Preclinical cardiovascular research using noninvasive radionuclide and hybrid imaging systems has been extensively developed in recent years. Single photon emission computed tomography (SPECT) is based on the molecular tracer principle and is an established tool in noninvasive imaging. SPECT uses gamma cameras and collimators to form projection data that are used to estimate (dynamic) 3-D tracer distributions in vivo. Recent developments in multipinhole collimation and advanced image reconstruction have led to sub-millimetre and sub-half-millimetre resolution SPECT in rats and mice, respectively. In this article we review applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained. We give examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by microSPECT, using small-animal models of cardiovascular disease.
引用
收藏
页码：1766 / 1777
页数：12
相关论文
共 50 条
  • [1] Small-animal SPECT and SPECT/CT: application in cardiovascular research
    Reza Golestani
    Chao Wu
    René A. Tio
    Clark J. Zeebregts
    Artiom D. Petrov
    Freek J. Beekman
    Rudi A. J. O. Dierckx
    Hendrikus H. Boersma
    Riemer H. J. A. Slart
    [J]. European Journal of Nuclear Medicine and Molecular Imaging, 2010, 37 : 1766 - 1777
  • [2] Adaptive small-animal SPECT/CT
    Furenlid, L. R.
    Moore, J. W.
    Freed, M.
    Kupinski, M. A.
    Clarkson, E.
    Liu, Z.
    Wilson, D. W.
    Woolfenden, J. M.
    Barrett, H. H.
    [J]. 2008 IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: FROM NANO TO MACRO, VOLS 1-4, 2008, : 1407 - +
  • [3] Small-Animal SPECT and SPECT/CT: Important Tools for Preclinical Investigation
    Franc, Benjamin L.
    Acton, Paul D.
    Mari, Carina
    Hasegawa, Bruce H.
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2008, 49 (10) : 1651 - 1663
  • [4] Compact CT/SPECT small-animal imaging system
    Kastis, GA
    Furenlid, LR
    Wilson, DW
    Peterson, TE
    Barber, HB
    Barrett, HH
    [J]. IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2004, 51 (01) : 63 - 67
  • [5] Compact CT/SPECT small-animal imaging system
    Kastis, GA
    Furenlid, LR
    Wilson, DW
    Peterson, TE
    Barber, HB
    Barrett, HH
    [J]. 2002 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORD, VOLS 1-3, 2003, : 797 - 801
  • [6] Anatomical priors to improve image quality in small-animal SPECT/CT
    Wells, R. Glenn
    [J]. 2007 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-11, 2007, : 4319 - 4323
  • [7] Small-animal SPECT dynamic cardiac imaging
    Johnson, Lindsay
    Guerraty, Marie
    Blankemeyer, Eric
    Mankoff, David
    Rader, Daniel
    Metzler, Scott
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2016, 57
  • [8] A new design for a SPECT small-animal imager
    Wilson, DW
    Barrett, HH
    Furenlid, LR
    [J]. 2001 IEEE NUCLEAR SCIENCE SYMPOSIUM, CONFERENCE RECORDS, VOLS 1-4, 2002, : 1826 - 1829
  • [9] Development of a Germanium Small-Animal SPECT System
    Johnson, Lindsay C.
    Ovchinnikov, Oleg
    Shokouhi, Sepideh
    Peterson, Todd E.
    [J]. IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2015, 62 (05) : 2036 - 2042
  • [10] High performance of an integrated PET/SPECT/CT system for small-animal imaging
    Magota, Keiichi
    Kubo, Naoki
    Kuge, Yuji
    Nishijima, Ken-ichi
    Zhao, Songji
    Tamaki, Nagara
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2010, 51
12345