Engineering genetically encoded fluorescent indicators for imaging of neuronal activity: Progress and prospects

被引：46
|
作者：
Shen, Yi [1 ]
Nasu, Yusuke [2 ]
Shkolnikov, Irene [1 ]
Kim, Anna [1 ]
Campbell, Robert E. [1 ,2 ]
机构：
[1] Univ Alberta, Dept Chem, Edmonton, AB, Canada
[2] Univ Tokyo, Grad Sch Sci, Dept Chem, Tokyo, Japan
来源：
NEUROSCIENCE RESEARCH | 2020年 / 152卷
基金：
美国国家卫生研究院; 加拿大自然科学与工程研究理事会; 日本学术振兴会;
关键词：
Genetically encoded indicators; Fluorescence imaging; Neuronal activity; Calcium ion; Membrane voltage; Neurotransmitters; NEURAL ACTIVITY; OPTICAL ELECTROPHYSIOLOGY; VOLTAGE INDICATOR; ACTION-POTENTIALS; PROTEIN; CA2+; PROBE; CALMODULIN; SENSOR; FLIES;
D O I：
10.1016/j.neures.2020.01.011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Genetically encoded fluorescent indicators have transformed the way neuroscientists record neuronal activities and interrogate the nervous system in vivo. In this review, we discuss recent advances and new additions to the toolkit of indicators for calcium ion entry, membrane voltage change, neurotransmitter release, and other neuronal molecular processes. We highlight new engineering approaches for indicator design and development, and identify key areas for future improvement. From molecular tool developers' perspective, we aim to provide practical information for neuroscientists to evaluate and choose the most appropriate indicators for enabling new insights into brain function. (C) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
引用
收藏
页码：3 / 14
页数：12
相关论文
共 50 条
  • [1] Genetically encoded indicators of neuronal activity
    Lin, Michael Z.
    Schnitzer, Mark J.
    NATURE NEUROSCIENCE, 2016, 19 (09) : 1142 - 1153
  • [2] Genetically encoded indicators of neuronal activity
    Michael Z Lin
    Mark J Schnitzer
    Nature Neuroscience, 2016, 19 : 1142 - 1153
  • [3] Bioluminescent Genetically Encoded Glutamate Indicators for Molecular Imaging of Neuronal Activity
    Petersen, Eric D.
    Lapan, Alexandra P.
    Franco, E. Alejandro Castellanos
    Fillion, Adam J.
    Crespo, Emmanuel L.
    Lambert, Gerard G.
    Grady, Connor J.
    Zanca, Albertina T.
    Orcutt, Richard
    Hochgeschwender, Ute
    Shaner, Nathan C.
    Gilad, Assaf A.
    ACS SYNTHETIC BIOLOGY, 2023, 12 (08): : 2301 - 2309
  • [4] Genetically Encoded Fluorescent Indicators for Organellar Calcium Imaging
    Suzuki, Junji
    Kanemaru, Kazunori
    Iino, Masamitsu
    BIOPHYSICAL JOURNAL, 2016, 111 (06) : 1119 - 1131
  • [5] Genetically Encoded Fluorescent Indicators for Imaging Brain Chemistry
    Bi, Xiaoke
    Beck, Connor
    Gong, Yiyang
    BIOSENSORS-BASEL, 2021, 11 (04):
  • [6] Synthetic and genetically encoded fluorescent neural activity indicators
    Deo, Claire
    Lavis, Luke D.
    CURRENT OPINION IN NEUROBIOLOGY, 2018, 50 : 101 - 108
  • [7] Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging
    Berlin, Shai
    Carroll, Elizabeth C.
    Newman, Zachary L.
    Okada, Hitomi O.
    Quinn, Carson M.
    Kallman, Benjamin
    Rockwell, Nathan C.
    Martin, Shelley S.
    Lagarias, J. Clark
    Isacoff, Ehud Y.
    NATURE METHODS, 2015, 12 (09) : 852 - +
  • [8] Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging
    Berlin S.
    Carroll E.C.
    Newman Z.L.
    Okada H.O.
    Quinn C.M.
    Kallman B.
    Rockwell N.C.
    Martin S.S.
    Lagarias J.C.
    Isacoff E.Y.
    Nature Methods, 2015, 12 (9) : 852 - 858
  • [9] Genetically encoded fluorescent indicators for 2-photon imaging
    Aggarwal, Abhi
    Podgorski, Kaspar
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
  • [10] Genetically encoded fluorescent indicators for live cell pH imaging
    Martynov, Vladimir I.
    Pakhomov, Alexey A.
    Deyev, Igor E.
    Petrenko, Alexander G.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2018, 1862 (12): : 2924 - 2939
12345