Pd and photoredox dual catalysis assisted decarboxylative ortho-benzoylation of N-phenyl-7-azaindoles

被引：12
|
作者：
Rajput, Shruti [1 ]
Kaur, Ramandeep [1 ]
Jain, Nidhi [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, New Delhi 110016, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 07期
关键词：
ALPHA-OXOCARBOXYLIC ACIDS; VISIBLE-LIGHT PHOTOCATALYSIS; C-H FUNCTIONALIZATION; KETO ACIDS; COUPLING REACTION; ACYLATION; 7-AZAINDOLES; DRIVEN; ARENES; ACYLARYLATION;
D O I：
10.1039/d1ob02338a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The directing group assisted decarboxylative ortho-benzoylation of N-aryl-7-azaindoles with alpha-keto acids has been achieved by synergistic visible light promoted photoredox and palladium catalysis. The approach tenders rapid entry to aryl ketone architectures from simple alpha-keto acid precursors via the in situ generation of a benzoyl radical intermediate. The transformation provides a range of ortho-benzoylated N-aryl-7-azaindoles, with excellent site-selectivity and good functional group compatibility under mild reaction conditions. Biological target predictions indicate that these molecules may serve as potential anti-cancer and anti-viral agents.
引用
收藏
页码：1453 / 1461
页数：9
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