A disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks' gestation in pregnancies destined to deliver small for gestational age infants

被引：8
|
作者：
Andres, Faith [1 ,2 ]
Wong, Georgia P. [1 ,2 ]
Walker, Susan P. [1 ,2 ]
MacDonald, Teresa M. [1 ,2 ]
Keenan, Emerson [1 ,2 ]
Cannon, Ping [1 ,2 ]
Nguyen, Tuong-Vi [1 ,2 ]
Hannan, Natalie J. [1 ,2 ]
Tong, Stephen [1 ,2 ]
Kaitu'u-Lino, Tu'uhevaha J. [1 ,2 ]
机构：
[1] Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, 163 Studley Rd, Heidelberg, Vic 3084, Australia
[2] Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia
来源：
PLACENTA | 2022年 / 117卷
基金：
英国医学研究理事会;
关键词：
ADAM12; Biomarker; FGR; SGA; Preeclampsia; FETAL-GROWTH RESTRICTION; MATERNAL SERUM; PREECLAMPSIA; DOPPLER; HEALTH; ROLES; RNA;
D O I：
10.1016/j.placenta.2021.11.001
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
First trimester circulating ADAM12 is reduced in fetal growth restriction (FGR) and preeclampsia. We measured plasma ADAM12 at 36 weeks' gestation preceding diagnosis of term preeclampsia or delivery of a small for gestational age (SGA; birthweight <10th centile) infant in two independent cohorts (Cohort 1 90 SGA, 41 preeclampsia, 862 controls; Cohort 2121 SGA 23 preeclampsia; 190 controls). ADAM12 was reduced with SGA in both cohorts (p = 0.0015 and 0.011 respectively), and further reduced with birthweight <5th centile (p = 0.0013 and 0.0058 respectively). This validates ADAM12 as an SGA biomarker near term. Circulating ADAM12 preceding preeclampsia was not consistently altered.
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页码：1 / 4
页数：4
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