Detection of bcr/abl mRNA in a case of chronic myelogenous leukemia in long-term remission:: CML or sensitivity of detection?

被引：0

作者：

Anguita, E ^{[1
]}

Villegas, A ^{[1
]}

Díaz-Mediavilla, J ^{[1
]}

González, FA ^{[1
]}

Del Potro, E ^{[1
]}

Espinós, D ^{[1
]}

机构：

[1] Hosp Univ San Carlos, Dept Hematol, Madrid 28040, Spain

来源：

HAEMATOLOGICA | 1998年 / 83卷 / 08期

关键词：

chronic myelogenous leukaemia; BCR/ABL; nested RT-PCR; Southern blot; remission; prolonged survival;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder which, after a chronic phase which lasts an average of 3 years, evolves Into an acute disease which is resistant to chemotherapy. Nevertheless, a few studies have reported cases In which partial or complete hematologic, cytogenetic and/or molecular remission of the disease were observed either spontaneously or after non intensive chemotherapy, with or without medullar aplasia. Some of these patients later relapsed into a blast crisis. We report a case of CML with clinical and hematologic remission for 19 years after two cycles of busulphan not causing medullar aplasia, negative for the BCR/ABL gene by Southern blot but with the gene's mRNA detectable by hot start nested RT-PCR. (C) 1998, Ferrata Storti Foundation.

引用

页码：744 / 747

页数：4

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