Telomere length and obesity

被引：73

作者：

Zannolli, Raffaella ^{[1
]}

Mohn, Angelika ^{[2
]}

Buoni, Sabrina ^{[1
]}

Pietrobelli, Angelo ^{[4
]}

Messina, Mario ^{[3
]}

Chiarelli, Francesco ^{[2
]}

Miracco, Clelia ^{[5
]}

机构：

[1] Univ Siena, Dept Pediat Obstet & Reprod Med, Sect Pediat, Policlin Le Scotte, I-53100 Siena, Italy

[2] Univ G dAnnunzio, Dept Pediat, Chieti, Italy

[3] Univ Siena, Dept Pediat Obstet & Reprod Med, Pediat Surg Sect, Policlin Le Scotte, I-53100 Siena, Italy

[4] Univ Verona, Sch Med, Pediat Unit, I-37100 Verona, Italy

[5] Univ Siena, Dept Human Pathol & Oncol, Sect Pathol Anat & Istol, Policlin Le Scotte, I-53100 Siena, Italy

来源：

ACTA PAEDIATRICA | 2008年 / 97卷 / 07期

关键词：

age-dependency; ageing; all child; chronic disease; obese children;

D O I：

10.1111/j.1651-2227.2008.00783.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim: To assess the telomere length in apparently healthy obese and normal-weight subjects. Methods: Seventy-six Caucasian subjects were chosen including 53 children ( age 8.2 +/- 3.5 years) and 23 adults (age 40.5 +/- 8.4 years). Among these, 22 ( 12 children and 10 adults) were obese with a body mass index (BMI, kg/m(2)) > 2 SD above the norm. Bioelectrical impedance analysis (BIA), measured with a multiple frequency analyzer, was used to estimate body composition. DNA extraction from white blood cells was used to estimate the telomere length by detection of terminal restriction fragments (TRF). Results: No difference was found between the TRF lengths of obese and normal children. Obese adults had shorter TRF lengths than adults who were not obese (mean TRF length difference, -884.5; 95% confidence intervals - 1727 to -41.8; t = 2.183; df = 17; p < 0.041). Conclusion: Obese adults have shorter telomeres than their normal-weight counterparts, while this phenomenon is not present in childhood.

引用

页码：952 / 954

页数：3

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