An efficient selective reduction of aromatic azides to amines employing BF3•OEt2/NaI:: Synthesis of pyrrolobenzodiazepines

被引：23
|
作者：
Kamal, Ahmed [1 ]
Shankaraiah, N. [1 ]
Markandeya, N. [2 ]
Reddy, Ch. Sanjeeva [2 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India
[2] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India
来源：
SYNLETT | 2008年 / 09期
关键词：
pyrrolo[2, 1-c][1,4] benzodiazepines; boron trifluoride diethyl etherate; sodium iodide; intramoleculor reductive-cyclization;
D O I：
10.1055/s-2008-1072742
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A selective and facile method for the reduction of aromatic azides to amines by employing borontrifluoride diethyl etherate and sodium iodide. This methodology has been applied towards the preparation of biologically important imine-containing pyrrolobenzodiazepines and their dilactams through intramolecular reductive-cyclization process. In this protocol the reagent systems are amenable for the generation of solution-phase combinatorial synthesis.
引用
收藏
页码：1297 / 1300
页数：4
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