Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels

被引：27

作者：

Nath, Arijit ^{[1
,2
]}

Molnar, Mate Andras ^{[1
]}

Csighy, Attila ^{[1
]}

Koszegi, Kornelia ^{[1
]}

Galambos, Ildiko ^{[2
]}

Huszar, Mara Pasztorne ^{[3
]}

Koris, Andras ^{[1
]}

Vatai, Gyula ^{[1
]}

机构：

[1] Szent Istvan Univ, Fac Food Sci, Dept Food Engn, Menesi St 44, H-1118 Budapest, Hungary

[2] Univ Pannonia, Fac Engn, Soos Erno Water Technol Res Ctr, Ullo Ut, H-3 Nagykanizsa, Hungary

[3] Szent Istvan Univ, Fac Food Sci, Dept Refrigerat & Livestock Prod Technol, Menesi St 43-45, H-1118 Budapest, Hungary

来源：

MEDICINA-LITHUANIA | 2018年 / 54卷 / 06期

关键词：

lactose-based prebiotics; probiotics; osteoporosis; blood lipid level; blood glucose level; CHAIN FATTY-ACIDS; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; BILE-SALT BIOTRANSFORMATIONS; ANGIOPOIETIN-LIKE PROTEIN-4; DIET-INDUCED OBESITY; BETA-CELL FUNCTION; IN-VITRO BINDING; GUT MICROBIOTA; INSULIN-RESISTANCE;

D O I：

10.3390/medicina54060098

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lactose-based prebiotics are synthesized by enzymatic- or microbial-biotransformation of lactose and have unique functional values. In this comprehensive review article, the biochemical mechanisms of controlling osteoporosis, blood-lipid, and glucose levels by lactose-based prebiotics and symbiosis with probiotics are reported along with the results of clinical investigations. Interaction between lactose-based prebiotics and probiotics reduces osteoporosis by (a) transforming insoluble inorganic salts to soluble and increasing their absorption to gut wall; (b) maintaining and protecting mineral absorption surface in the intestine; (c) increasing the expression of calcium-binding proteins in the gut wall; (d) remodeling osteoclasts and osteoblasts formation; (e) releasing bone modulating factors; and (f) degrading mineral complexing phytic acid. Lactose-based prebiotics with probiotics control lipid level in the bloodstream and tissue by (a) suppressing the expressions of lipogenic-genes and enzymes; (b) oxidizing fatty acids in muscle, liver, and adipose tissue; (c) binding cholesterol with cell membrane of probiotics and subsequent assimilation by probiotics; (d) enzymatic-transformations of bile acids; and (e) converting cholesterol to coprostanol and its defecation. Symbiosis of lactose-based prebiotics with probiotics affect plasma glucose level by (a) increasing the synthesis of gut hormones plasma peptide-YY, glucagon-like peptide-1 and glucagon-like peptide-2 from entero-endocrine L-cells; (b) altering glucose assimilation and metabolism; (c) suppressing systematic inflammation; (d) reducing oxidative stress; and (e) producing amino acids. Clinical investigations show that lactose-based prebiotic galacto-oligosaccharide improves mineral absorption and reduces hyperlipidemia. Another lactose-based prebiotic, lactulose, improves mineral absorption, and reduces hyperlipidemia and hyperglycemia. It is expected that this review article will be of benefit to food technologists and medical practitioners.

引用

页数：28