BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

被引：90

作者：

Pathania, Shailja ^{[1
,4
]}

Jenna Nguyen ^{[4
]}

Hill, Sarah J. ^{[4
]}

Scully, Ralph ^{[2
,6
]}

Adelmant, Guillaume O. ^{[3
,4
,5
]}

Marto, Jarrod A. ^{[3
,4
,5
]}

Feunteun, Jean ^{[7
]}

Livingston, David M. ^{[1
,4
]}

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[4] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA

[5] Dana Farber Canc Inst, Blais Prote Ctr, Boston, MA 02215 USA

[6] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[7] Inst Gustave Roussy, UMR8200, Lab Stabilite Genet & Oncogenese, F-94805 Villejuif, France

来源：

MOLECULAR CELL | 2011年 / 44卷 / 02期

基金：

美国国家卫生研究院;

关键词：

NUCLEOTIDE EXCISION-REPAIR; STALLED REPLICATION FORKS; POLYMERASE-ETA; HOMOLOGOUS RECOMBINATION; XERODERMA-PIGMENTOSUM; GENOMIC INSTABILITY; S-PHASE; CHECKPOINT; BREAST; CANCER;

D O I：

10.1016/j.molcel.2011.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR.

引用

页码：235 / 251

页数：17

共 50 条

[1] THE EXPRESSION AND CHROMOSOMAL ASSIGNMENTS OF GENES REQUIRED FOR REPAIR OF UV-INDUCED DNA DAMAGE
LALLEY, PA
DIAZ, JA
FRANCIS, AA
DUNN, WC
REGAN, JD
CYTOGENETICS AND CELL GENETICS, 1984, 37 (1-4): : 516 - 516
[2] UV-induced DNA damage and repair: a review
Sinha, RP
Häder, DP
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2002, 1 (04) : 225 - 236
[3] UV-induced DNA damage and repair: a review
Rajeshwar P. Sinha
Donat-P. Häder
Photochemical & Photobiological Sciences, 2002, 1 : 225 - 236
[4] THE EXPRESSION AND CHROMOSOMAL ASSIGNMENTS OF GENES REQUIRED FOR REPAIR OF UV-INDUCED DNA DAMAGE IN MAN
LALLEY, PA
DIAZ, JA
FRANCIS, AA
DUNN, WC
REGAN, JD
RADIATION RESEARCH, 1983, 94 (03) : 663 - 664
[5] DNA-POLYMERASES REQUIRED FOR REPAIR OF UV-INDUCED DAMAGE IN SACCHAROMYCES-CEREVISIAE
BUDD, ME
CAMPBELL, JL
MOLECULAR AND CELLULAR BIOLOGY, 1995, 15 (04) : 2173 - 2179
[6] The Cartography of UV-induced DNA Damage Formation and DNA Repair
Hu, Jinchuan
Adar, Sheera
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2017, 93 (01) : 199 - 206
[7] Immunochemical detection of UV-induced DNA damage and repair
Cooke, MS
Podmore, ID
Mistry, N
Evans, MD
Herbert, KE
Griffiths, HR
Lunec, J
JOURNAL OF IMMUNOLOGICAL METHODS, 2003, 280 (1-2) : 125 - 133
[8] UV-induced DNA damage in carcinogenesis and its repair
Nishigori, C
JOURNAL OF DERMATOLOGICAL SCIENCE, 2000, 23 : S41 - S44
[9] Alternative repair pathways for UV-induced DNA damage
Yasui, A
McCready, SJ
BIOESSAYS, 1998, 20 (04) : 291 - 297
[10] UV-INDUCED DAMAGE AND REPAIR IN CENTROMERE DNA OF YEAST
RESNICK, MA
WESTMORELAND, J
AMAYA, E
BLOOM, K
MOLECULAR & GENERAL GENETICS, 1987, 210 (01): : 16 - 22

← 1 2 3 4 5 →