Value of (1-3)-β-D-glucan, Candida mannan and Candida DNA detection in the diagnosis of candidaemia

被引：16

作者：

Mokaddas, E. ^{[1
]}

Khan, Z. U. ^{[1
]}

Ahmad, S. ^{[1
]}

Nampoory, M. R. N. ^{[2
]}

Burhamah, M. ^{[3
]}

机构：

[1] Kuwait Univ, Dept Microbiol, Fac Med, Shuwaikh, Kuwait

[2] Hamed Al Essa Organ Transplant Ctr, Shuwaikh, Kuwait

[3] Al Sabah Hosp, NBK Canc Ward, Shuwaikh, Kuwait

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2011年 / 17卷 / 10期

关键词：

(1-3)-beta-D-glucan; Candida DNA; Candida mannan; candidaemia; diagnosis; INVASIVE FUNGAL-INFECTIONS; BETA-D-GLUCAN; ANTIMANNAN ANTIBODIES; ASSAY; PCR; IDENTIFICATION; DUBLINIENSIS; IMMUNOASSAY; ANTIGENS; LEUKEMIA;

D O I：

10.1111/j.1469-0691.2011.03608.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study determined the value of (1,3)-beta-D-glucan (BDG), Candida mannan (MN) and Candida species-specific DNA as surrogates for diagnosis of candidaemia. Thirty-nine patients yielding Candida species in blood cultures were investigated for presence of BDG, MN and Candida species-specific DNA in serum samples. The Candida spp. bloodstream isolates included C. albicans (n = 16), C. tropicalis (n = 10), C. parapsilosis (n = 7), C. glabrata (n = 3) and C. dubliniensis (n = 3). Positivity of the three markers was as follows: Candida DNA for corresponding Candida species, 100%; BDG, 87%; MN, 59%. Despite varying sensitivities of these biomarkers, they provided a useful adjunct to the diagnosis of candidaemia.

引用

页码：1549 / 1553

页数：6

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