The effect of combined diet and exercise intervention on body weight and the serum GPIHBP1 concentration in overweight/obese middle-aged women

Background: The relationship between the effects of diet and exercise intervention and the body weight associated with the serum lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL) and glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1) concentrations has not been elucidated. Methods: Sixty-six overweight/obese middle aged women were assigned to the diet and exercise intervention for 4 months. They were divided into 2 groups followed by the body mass index (BMI) decreased > 3% (n = 41) and < 3% (n = 25). Serum lipids, lipoproteins and the LPL, HTGL, GPIHBPI concentrations were determined. Results: The cases in which the BMI decreased > 3% exhibited significant improvement of diagnostic markers compared with the cases with < 3% decrease after the intervention. The LPL concentration did not significantly change, but GPIHBP1 increased significantly after the intervention. The increased GPIHBP1 was significantly associated with decreased body weight. Multiple regression analysis indicated a strong association between GPIHBPI and percentage of body fat. Conclusions: The diet and exercise intervention significantly increased the serum GPIHBP1 concentration in association with a decrease in body weight and percentage of body fat. These results suggest that GPIHBPI is a better marker for body weight decrease than LPL.