Non-specific effects of vaccination on child survival? A prospective study in Senegal

被引:51
|
作者
Elguero, E
Simondon, KB
Vaugelade, J
Marra, A
Simondon, F
机构
[1] IRD, Lab Populat Environm & Dev, F-34394 Montpellier, France
[2] IRD, US Niakhar Espace Rech Integree Sante Populat, Dakar 99341, Senegal
关键词
vaccines; diphtheria-tetanus-pertussis; measles; mortality; Senegal; Africa;
D O I
10.1111/j.1365-3156.2005.01479.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
OBJECTIVES Several studies have shown an association between vaccination and child mortality in developing countries. The present paper examines this issue using data from a Senegalese rural area which has been monitored from 1983 to the present. METHODS We analysed two birth cohorts, comprising 7796 and 3573 persons who had received either BCG and DTP (diphtheria-tetanus-pertussis) simultaneously or neither of these vaccines, and who had been followed from birth to 2 years of age. The association between vaccinations and mortality was assessed by Cox proportional hazards model. RESULTS Mortality ratios for recipients of the BCG/DTP combination were 0.59 (95% CI: 0.46-0.74) for the first cohort and 0.70 (0.50-0.97) for the second cohort. Mortality ratios for measles vaccine recipients were 0.98 (0.75-1.27) for the first cohort and 0.87 (0.57-1.30) for the second cohort. CONCLUSIONS The BCG/DTP combination was associated with a reduction in mortality whereas measles vaccination was not associated with mortality.
引用
收藏
页码:956 / 960
页数:5
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