DNMT3A-448A>G polymorphism and cancer risk: a meta-analysis

被引：6

作者：

Liu, C. H. ^{[1
]}

Tao, T. ^{[1
]}

Jiang, L. ^{[1
]}

Xu, B. ^{[2
]}

Zhang, L. ^{[2
]}

Lu, K. ^{[2
]}

Zhang, X. W. ^{[1
]}

Chen, S. Q. ^{[1
]}

Liu, D. C. ^{[1
]}

Chen, M. ^{[2
]}

机构：

[1] Southeast Univ, Med Sch, Nanjing, Jiangsu, Peoples R China

[2] Southeast Univ, Affiliated Zhongda Hosp, Dept Urol, Nanjing, Jiangsu, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Cancer; DNA (cytosine-5)-methyltransferase 3A; Meta-analysis; Single nucleotide polymorphism; DNA METHYLTRANSFERASES; GASTRIC-CANCER;

D O I：

10.4238/2015.April.17.14

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies have been conflicting. To clarify the role of DNMT3A polymorphisms in cancer, we conducted a meta-analysis of 2014 cases and 3089 control subjects. Odds ratios with 95% confidence intervals were estimated to evaluate the association between the DNMT3A -448A>G polymorphism and cancer risk. The results showed that DNMT3A may be a protective factor against all cancer types and colorectal cancer groups. Further studies should be conducted including different ethnicities and large population sizes to generate a comprehensive conclusion.

引用

页码：3640 / 3649

页数：10

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DNMT3A-448A&gt;G polymorphism and cancer risk: a meta-analysis

DNMT3A-448A>G polymorphism and cancer risk: a meta-analysis