Mitochondrial targeting of selective electron scavengers: Synthesis and biological analysis of hemigramicidin-TEMPO conjugates

被引：135
|
作者：
Wipf, P [1 ]
Xiao, JB
Jiang, JF
Belikova, NA
Tyurin, VA
Fink, MP
Kagan, VE
机构：
[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15260 USA
[3] Univ Pittsburgh, Dept Crit Care Med, Pittsburgh, PA 15260 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 36期
关键词：
D O I：
10.1021/ja053679l
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthetic hemigramicidin S-peptidyl TEMPO conjugates are effectively delivered into cells and mitochondria, where they act as electron scavengers and exert protection against apoptosis. Our delivery approach is based on the use of specific structural signaling features recognizable by cells as mitochondria targeting sequences and offers considerable therapeutic anti-apoptotic potential. Copyright © 2005 American Chemical Society.
引用
收藏
页码：12460 / 12461
页数：2
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