Synthesis of 4′-epi-iodo-4′-deoxy-daunorubicin, a potential cancer radiotherapeutic agent

被引：5
|
作者：
Murali, D [1 ]
DeJesus, OT [1 ]
机构：
[1] Univ Wisconsin, Sch Med, Dept Phys Med, Madison, WI 53706 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 23期
关键词：
D O I：
10.1016/S0960-894X(98)00616-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We have prepared 4'-epi-iodo-4'-deoxy-daunorubicin (IDDNR)(1), a doxorubicin analog, via a 5-step synthesis involving a protected daunorubicin triflate derivative (4). This triflate derivative will allow the facile and regiospecific nucleophilic preparation of I-125 or Br-80m labelled analogs of IDDNR. Auger electron-emitting I-125- or Br-80m-labelled analogs of IDDNR may have potential as cancer radiotherapeutic agents. (C) 1998 Elsevier Science Ltd. All rights reserved.
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收藏
页码：3419 / 3422
页数：4
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