Hepatic decompensation associated with an interferon-free antiviral therapy in patients with HCV-cirrhosis

被引：0
|
作者：
Batskikh, S. N. [1 ]
Vinnitskaya, E. V. [1 ]
Sandler, Yu G. [1 ]
Khaimenova, T. Yu [1 ]
机构：
[1] AS Loginov Moscow Clin Sci & Pract Ctr, Moscow City Dept Hlth, Moscow, Russia
来源：
TERAPEVTICHESKII ARKHIV | 2018年 / 90卷 / 11期
关键词：
hepatitis C; cirrhosis; antiviral therapy; direct-acting antiviral agents; decompensation; SUSTAINED VIROLOGICAL RESPONSE; C VIRUS-INFECTION; LACTIC-ACIDOSIS;
D O I：
10.26442/terarkh2018901167-73
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Today, there is no complete clarity about the pathogenetic mechanisms of the hepatic decompensation in patients with HCV-cirrhosis during the course of direct-acting antiviral (DAAs) therapy. The current article describes several clinical observations of decompensation (with the development of liver failure and portal hypertension) in cirrhotic patients during the course of DAAs-therapy of hepatitis C. The authors present contemporary views and their own assumptions about the possible mechanisms of the hepatic decompensation associated with DAAs-therapy in patients with liver cirrhosis.
引用
收藏
页码：67 / 73
页数：7
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