Safety and efficacy of transcutaneous vaccination using a patch with the live-attenuated measles vaccine in humans

被引：42
|
作者：
Etchart, Nathalie
Hennino, Ana
Friede, Martin
Dahel, Karima
Dupouy, Monique
Goujon-Henry, Catherine
Nicolas, Jean-Francois
Kaiserlian, Dominique
机构：
[1] INSERM, U 404, F-69007 Lyon, France
[2] Univ Lyon 1, F-69003 Lyon, France
[3] IFR 128, F-69007 Lyon, France
[4] INSERM, U503, F-69007 Lyon, France
[5] World Hlth Org Initiat Vaccine Res, CH-12211 Geneva, Switzerland
[6] Hosp Civ Lyon, Ctr Hosp Lyon Sud, Serv Immunol Clin Allergol, F-69495 Pierre Benite, France
来源：
VACCINE | 2007年 / 25卷 / 39-40期
关键词：
transcutaneous administration; measles virus; Vaccines; IgA;
D O I：
10.1016/j.vaccine.2007.07.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Transcutaneous immunisation (TCI) using a skin patch is a non-invasive vaccination route relevant to mass vaccination against infectious diseases. This phase I/II clinical study, documents that TCI of human adult volunteers with the live-attenuated measles vaccine ROUVAX((R)) is safe and poorly reactogenic. It promotes induction of measles-specific salivary IgA and a tendency to increased frequency of NIV-specific IFN-gamma-producing T cells. However, in contrast to the subcutaneous route, TCI failed to evoke neutralising NIV-specific serum antibodies. Thus, alternative delivery methods and/or devices providing optimal uptake by skin DC should be considered for live-attenuated virus vaccines, such as the measles vaccine. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6891 / 6899
页数：9
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