Preparation and Characterization of Azithromycin-loaded Nanostructured Lipid Carriers

被引：2
|
作者：
Wu, Jiaying [1 ]
Xia, Qiang [1 ]
机构：
[1] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing 210096, Peoples R China
来源：
APPLICATION OF CHEMICAL ENGINEERING, PTS 1-3 | 2011年 / 236-238卷
关键词：
Azithromycin; High-pressure Homogenization; Nanostructured Lipid Carriers; Particle Size;
D O I：
10.4028/www.scientific.net/AMR.236-238.2917
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
To function lipophilic drug Azithromycin (AZM) as ophthalmic preparation, Azithromycin-loaded Nanostructured Lipid Carriers (AZM-NLC) were prepared by High Pressure Homogenization (HPH), and its stability was analyzed afterwards. Well-dissolved lipids of Azithromycin were selected, how the ratio of surfactants to lipids influenced the preparation of AZM-NLC was studied, and mature surfactant system was chosen. The optimized ratio of lipid carriers to emulsifiers [polyoxyethylene (40) stearate - Poloxamer188 (7:3)] in this study was 1:6, and the final drug-capacity rate was 0.5%. Obtained by photon correlation spectroscopy, the mean particle size of AZM-NLC was 76 +/- 2 nm. The results showed that AZM-NLC had kept stable for 15 days, and mean particle size increased to 83 nm after four months.
引用
收藏
页码：2917 / 2920
页数：4
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