Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/- mice

被引：3
|
作者：
Mishima, Tetsuya [1 ,2 ]
Iwabuchi, Kazuya [1 ]
Fujii, Satoshi [2 ]
Tanaka, Shin-Ya [3 ]
Ogura, Hisako [1 ]
Watano-Miyata, Keiko [1 ,2 ]
Ishimori, Naoki [2 ]
Andoh, Yasuhiro [1 ,2 ]
Nakai, Yukihito [1 ,2 ]
Iwabuchi, Chikako [1 ]
Ato, Manabu [1 ]
Kitabatake, Akira
Tsutsui, Hiroyuki [2 ]
Onoe, Kazunori [1 ]
机构：
[1] Hokkaido Univ, Inst Med Genet, Res Sect Pathophysiol,Div Immunobiol, Kita Ku, Sapporo, Hokkaido, Japan
[2] Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Sapporo, Hokkaido 0600815, Japan
[3] Hokkaido Univ, Grad Sch Med, Dept Cellular & Mol Pathol, Sapporo, Hokkaido 0600815, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2008年 / 21卷 / 02期
关键词：
atherosclerosis; innate immunity; macrophage; phagocytosis;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Allograft inflammatory factor (AIF)-1, originally cloned from a rat heart allograft under chronic rejection, is induced in various inflammatory conditions including atherosclerosis. Using mouse AIF-1 transfected macrophages and AIF-1 transgenic (AIF-1(Tg)) mice, we analyzed the influence of AIF-1 overexpression on macrophage phagocytosis and the development of atherosclerosis. The AIF-1 transfectants showed significantly increased phagocytosis of latex beads and E. coli BioParticles as well as incorporation of acetylated low-density lipoprotein (LDL) compared to those of vector controls. Concordant results were obtained with elicited peritoneal exudate cells from AIF-1(Tg) mice. When AIF-1(Tg) mice were crossbred with apolipoprotein E knockout mice (ApoE(-/-)), these AIF-1(Tg) ApoE(-/-) mice developed significantly increased atherosclerotic lesions compared to ApoE(-/-) mice. These results suggest that enhanced AIF-1 expression leads to augmented incorporation of degenerated LDL by macrophages and promotes development of atherosclerotic vasculopathy.
引用
收藏
页码：181 / 187
页数：7
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