Collagen biology and non-invasive biomarkers of liver fibrosis

被引：120

作者：

Karsdal, Morten A. ^{[1
]}

Daniels, Samuel J. ^{[1
]}

Nielsen, Signe Holm ^{[1
]}

Bager, Cecilie ^{[1
]}

Rasmussen, Daniel G. K. ^{[1
]}

Loomba, Rohit ^{[2
,3
]}

Surabattula, Rambabu ^{[2
,3
]}

Villesen, Ida Falk ^{[1
,4
]}

Luo, Yi ^{[5
]}

Shevell, Diane ^{[5
]}

Gudmann, Natasja S. ^{[1
]}

Nielsen, Mette J. ^{[1
]}

George, Jacob ^{[6
,7
]}

Christian, Rose ^{[5
]}

Leeming, Diana J. ^{[1
]}

Schuppan, Detlef ^{[8
,9
,10
]}

机构：

[1] Nordic Biosci, Fibrosis Biomarkers & Res, Herlev, Denmark

[2] Univ Calif San Diego, NAFLD Res Ctr, Div Gastroenterol, San Diego, CA 92103 USA

[3] Univ Calif San Diego, NAFLD Res Ctr, Div Epidemiol, San Diego, CA 92103 USA

[4] Univ Copenhagen, Copenhagen, Denmark

[5] Bristol Myers Squibb, Innovat Med, Princeton, NJ USA

[6] Univ Sydney, Westmead Inst Med Res, Storr Liver Ctr, Westmead, NSW, Australia

[7] Westmead Hosp, Westmead, NSW, Australia

[8] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02115 USA

[9] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Translat Immunol, Mainz, Germany

[10] Johannes Gutenberg Univ Mainz, Res Ctr Immune Therapy, Mainz, Germany

来源：

LIVER INTERNATIONAL | 2020年 / 40卷 / 04期

关键词：

biomarker; cirrhosis; collagen; fibrogenesis; fibrolysis; fibrosis; HBV; HCV; liver; monitoring; NAFLD; NASH; non-invasive; peptide; plasma; procollagen; serum; treatment; EXTRACELLULAR-MATRIX; III COLLAGEN; BIOCHEMICAL MARKERS; HYALURONIC-ACID; SERUM MARKERS; IV COLLAGEN; C5; DOMAIN; DISEASE; TURNOVER; PROGRESSION;

D O I：

10.1111/liv.14390

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non-alcoholic fatty liver disease (NAFLD). In particular, there is a need for diagnostic and prognostic tools, as well as predictive biomarkers that reflect the efficacy of interventions, as described by the BEST criteria (Biomarkers, EndpointS, and other Tools Resource). This review covers the various liver collagens, their functional role in tissue homeostasis and delineates the common nomenclature for biomarkers based on BEST criteria. It addresses the common confounders affecting serological biomarkers, and describes defined collagen epitope biomarkers that originate from the dynamic processes of extracellular matrix (ECM) remodelling during liver injury.

引用

页码：736 / 750

页数：15

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