Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population

被引：4
|
作者：
Wu, Lin [1 ,2 ,3 ]
Chen, Fengping [1 ,2 ,3 ]
Wei, Jun [4 ]
Shen, Yan [1 ,2 ,3 ]
Xu, Qi [1 ,2 ,3 ]
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100073, Peoples R China
[2] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100073, Peoples R China
[3] Tsinghua Univ, Peking Union Med Coll, Beijing 100073, Peoples R China
[4] Univ Highlands & Isl, Div Hlth Res, Ctr Hlth Sci, Old Perth Rd, Inverness IV2 3JH, Scotland
来源：
PSYCHIATRY RESEARCH | 2016年 / 241卷
关键词：
Tetraspanin; 18; Schizophrenia; Heterogeneity; GENOME-WIDE ASSOCIATION; BIPOLAR DISORDER; SUSCEPTIBILITY; VARIANTS; FAMILIES; GENDER; LOCUS; RISK; GENE;
D O I：
10.1016/j.psychres.2016.03.057
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
A genome-wide association study of Han Chinese samples identified three single-nucleotide polymorphisms in the tetraspanin 18 (TSPAN18) gene to be associated with schizophrenia. However, the replication of the TSPANI8 association was inconsistent across studies. To explore the possible reason for poor replication, we conducted a case-control study to validate the TSPAN18 finding in an independent Chinese sample. The frequency of rs11038167 minor allele (A) was significantly higher only in female patients with thought disorder. Our result suggested that the TSPANI8 gene may be involved in the development of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia. (C) 2016 Published by Elsevier Ireland Ltd.
引用
收藏
页码：263 / 266
页数：4
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