Mechanism-based inactivation of alpha-chymotrypsin

被引：3
|
作者：
Ohba, T [1 ]
Tsuchiya, N [1 ]
Nishimura, K [1 ]
Ikeda, E [1 ]
Wakayama, J [1 ]
Takei, H [1 ]
机构：
[1] TOKYO INST TECHNOL,INTERDISCIPLINARY GRAD SCH SCI & ENGN,MIDORI KU,YOKOHAMA,KANAGAWA 226,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 05期
关键词：
D O I：
10.1016/0960-894X(96)00065-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The peptidyl ester derivatives of 2,2-dichlorocyclopropanol and the amide derivative of 2,2-dichlorocyclopropylamine were prepred as novel mechanism-based inactivators of alpha-chymotrypsin. The esters inactivated alpha-chymotrypsin irreversibly but the amide did not show any irreversible inhibitory activity toward alpha-chymotrypsin.
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页码：543 / 546
页数：4
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