Proteogenomic Characterization of Human Early-Onset Gastric Cancer

被引：207

作者：

Mun, Dong-Gi ^{[1
]}

Bhin, Jinhyuk ^{[2
,3
,4
]}

Kim, Sangok ^{[5
,6
]}

Kim, Hyunwoo ^{[7
,8
]}

Jung, Jae Hun ^{[9
]}

Jung, Yeonjoo ^{[5
,6
]}

Jang, Ye Eun ^{[5
,6
]}

Park, Jong Moon ^{[10
]}

Kim, Hokeun ^{[1
]}

Jung, Yeonhwa ^{[5
,6
]}

Lee, Hangyeore ^{[1
]}

Bae, Jingi ^{[1
]}

Back, Seunghoon ^{[1
]}

Kim, Su-Jin ^{[1
]}

Kim, Jieun ^{[5
,6
]}

Park, Heejin ^{[7
]}

Li, Honglan ^{[11
]}

Hwang, Kyu-Baek ^{[11
]}

Park, Young Soo ^{[12
]}

Yook, Jeong Hwan ^{[13
]}

Kim, Byung Sik ^{[13
]}

Kwon, Sun Young ^{[14
]}

Ryu, Seung Wan ^{[14
]}

Park, Do Youn ^{[15
]}

Jeon, Tae Yong ^{[16
]}

Kim, Dae Hwan ^{[16
]}

Lee, Jae-Hyuck ^{[17
]}

Han, Sang-Uk ^{[18
]}

Song, Kyu Sang ^{[19
]}

Park, Dongmin ^{[20
]}

Park, Jun Won ^{[20
]}

Rodriguez, Henry ^{[21
]}

Kim, Jaesang ^{[5
,6
]}

Lee, Hookeun ^{[10
]}

Kim, Kwang Pyo ^{[9
]}

Yang, Eun Gyeong ^{[22
]}

Kim, Hark Kyun ^{[20
]}

Paek, Eunok ^{[7
]}

Lee, Sanghyuk ^{[5
,6
]}

Lee, Sang-Won ^{[1
]}

Hwang, Daehee ^{[2
,3
]}

机构：

[1] Korea Univ, Ctr Proteogenome Res, Dept Chem, Seoul 136701, South Korea

[2] DGIST, Inst Basic Sci, Dept New Biol, Daegu 711873, South Korea

[3] DGIST, Inst Basic Sci, Ctr Plant Aging Res, Daegu 711873, South Korea

[4] Netherlands Canc Inst, Oncode Inst, Div Mol Pathol, NL-1066 CX Amsterdam, Netherlands

[5] Ewha Womans Univ, Dept Life Sci, Seoul 120750, South Korea

[6] Ewha Womans Univ, Ewha Res Ctr Syst Biol, Seoul 120750, South Korea

[7] Hanyang Univ, Dept Comp Sci & Engn, Seoul 133791, South Korea

[8] Korea Inst Sci & Technol Informat, Res Data Hub Ctr, Daejeon 34141, South Korea

[9] Kyung Hee Univ, Coll Appl Sci, Dept Appl Chem, Yongin 446701, South Korea

[10] Gachon Univ, Gachon Coll Pharm, Gachon Inst Pharmaceut Sci, Incheon 406799, South Korea

[11] Soongsil Univ, Sch Comp Sci & Engn, Seoul 156743, South Korea

[12] Univ Ulsan, Asan Med Ctr, Dept Pathol, Coll Med, Seoul 138873, South Korea

[13] Univ Ulsan, Asan Med Ctr, Dept Surg, Coll Med, Seoul 138873, South Korea

[14] Keimyung Univ, Dept Surg, Sch Med, Daegu 700712, South Korea

[15] Pusan Natl Univ, Dept Pathol, Sch Med, Busan 602739, South Korea

[16] Pusan Natl Univ, Dept Surg, Sch Med, Busan 602739, South Korea

[17] Chonnam Natl Univ, Dept Pathol, Med Sch, Gwangju 501746, South Korea

[18] Ajou Univ, Dept Surg, Sch Med, Suwon 443380, South Korea

[19] Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon 301747, South Korea

[20] Natl Canc Ctr, Goyang 410769, South Korea

[21] NCI, Off Canc Clin Prote Res, NIH, Bethesda, MD 20892 USA

[22] Korea Inst Sci & Technol, Biomed Res Inst, Seoul 136791, South Korea

来源：

CANCER CELL | 2019年 / 35卷 / 01期

关键词：

MICROSATELLITE INSTABILITY; MOLECULAR SUBTYPES; SIGNALING PATHWAY; DATABASE SEARCH; ACCURATE MASS; IDENTIFICATION; MUTATIONS; DISCOVERY; GENE; KINASE;

D O I：

10.1016/j.ccell.2018.12.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune-and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.

引用

页码：111 / +

页数：24

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