Genomic structure and regulation of mitochondrial uncoupling protein genes in mammals and plants

被引:13
|
作者
Nogueira, FTS
Borecky, J
Vercesi, AE
Arruda, P [1 ]
机构
[1] Univ Estadual Campinas, Ctr Biol Mol & Engn Genet, BR-13083970 Campinas, SP, Brazil
[2] Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin NMCE, BR-13083970 Campinas, SP, Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Genet & Evolucao, BR-13083970 Campinas, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
expression profile; mitochondria; transcription regulation; uncoupling protein;
D O I
10.1007/s10540-005-2886-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Uncoupling mitochondrial proteins (UCPs) belong to a discrete family within the mitochondrial anion carrier superfamily. Several uncoupling protein types have been found in mitochondria from mammals and plants, as well as in fishes, fungi, and protozoa. Mammalian UCPs and plant uncoupling proteins (PUMPs) form five distinct subfamilies. Only subfamily III contains both plant and animal uncoupling proteins, as well as UCPs from primitive eukaryotic organisms, which suggest that this group may represent an ancestral cluster from which other UCPs/PUMPs may have evolved. Genetic data indicate that UCPs/PUMPs are regulated at the transcriptional, post-transcriptional, and translational levels. Tissue/organ- and stress-specific gene expression suggests that UCPs/PUMPs are involved in the general balance of basic energy expenditure, protection against reactive oxygen species, and thermogenesis. Finally, the simultaneous occurrence of PUMP and alternative oxidase, another energy-dissipating system in plant mitochondria, raises the question of their response to biotic and abiotic stress at the transcriptional and functional levels.
引用
收藏
页码:209 / 226
页数:18
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