Behavioral effects of angiotensin II microinjected into CA1 hippocampal area

被引：26
|
作者：
Belcheva, I [1 ]
Georgiev, V [1 ]
Chobanova, M [1 ]
Hadjiivanova, C [1 ]
机构：
[1] BULGARIAN ACAD SCI,INST PHYSIOL,LAB EXPT PSYCHOPHARMACOL,BU-1113 SOFIA,BULGARIA
来源：
NEUROPEPTIDES | 1997年 / 31卷 / 01期
关键词：
D O I：
10.1016/S0143-4179(97)90021-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The behavioral responses of rats to bilateral microinjections of angiotensin II (ATII) at doses of 0.1, 0.5 and 1.0 mu g into the hippocampal CA1 area of male Sprague-Dawley rats were studied. ATII affected locomotor activity (the number of horizontal and vertical movements) in a dose-related U-shaped manner. In the elevated plus-maze experiments, ATII at a dose of 0.1 mu g microinjected bilaterally into the CAI hippocampal area increased the number of entries into the open arms, suggesting some anxiolytic effect.
引用
收藏
页码：60 / 64
页数：5
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