Mean corpuscular hemoglobin concentration correlates with prognosis of resected hepatocellular carcinoma

被引：8

作者：

Kong, Weihao ^{[1
,2
,3
,4
]}

Zheng, Jun ^{[2
,3
,4
]}

Chen, Liang ^{[2
,3
,4
]}

Zuo, Xiaomin ^{[5
]}

Wang, Hengyi ^{[1
]}

Wang, Xingyu ^{[1
]}

Yao, Jia ^{[2
,3
,4
]}

Chen, Wei ^{[5
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Dept Emergency Med, Hefei 230022, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Hepat Surg, Guangzhou 510630, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 3, Liver Transplantat Ctr, Guangzhou 510630, Peoples R China

[4] Sun Yat Sen Univ, Key Lab Liver Dis Biotherapy & Translat Med, Guangdong Higher Educ Inst, Guangdong Key Lab Liver Dis Res,Affiliated Hosp, Guangzhou 510630, Peoples R China

[5] Anhui Med Univ, Affiliated Hosp 1, Dept Gen Surg, Hefei 230022, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 04期

基金：

安徽省自然科学基金;

关键词：

hepatectomy; hepatocellular carcinoma; mean corpuscular hemoglobin concentration; overall survival; recurrence-free survival; TO-LYMPHOCYTE RATIO; LIVER RESECTION; ANEMIA; PLATELET; HYPOXIA; CANCER; CHEMOTHERAPY; NEUTROPHIL; SURVIVAL; IMPACT;

D O I：

10.2217/bmm-2019-0224

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To evaluate the prognostic role of mean corpuscular hemoglobin concentration (MCHC) in hepatocellular carcinoma (HCC) after hepatectomy. Patients & methods: A total of 289 HCC patients were classified into two groups based on the cut-off value of MCHC. Significant prognostic factors were screened by univariate and multivariate analysis. Results: Low MCHC value was significantly associated with tumor diameter (p = 0.004) and vascular invasion (p = 0.038). Besides, Cox regression analysis showed that low MCHC was significantly associated with poor prognostic outcomes with HCC after hepatectomy (overall survival: hazard ratio: 0.372; 95% CI: 0.206-0.672; p = 0.001; recurrence-free survival: hazard ratio: 0.450; 95% confidence interval: 0.317-0.638; p < 0.001). Conclusion: Preoperative MCHC can predict prognosis for patients with HCC, and the lower MCHC value was associated with poor prognosis after hepatectomy.

引用

页码：257 / 269

页数：13

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