Novel piperidinyloxy oxazolidinone antimicrobial agents

被引：16

作者：

Weidner-Wells, MA ^{[1
]}

Boggs, CM ^{[1
]}

Foleno, BD ^{[1
]}

Wira, E ^{[1
]}

Bush, K ^{[1
]}

Goldschmidt, RM ^{[1
]}

Hlasta, DJ ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Drug Discovery, Raritan, NJ 08869 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(01)00305-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oxazolidinone antibacterial agents, where the N-substituted piperazinyl group of eperezolid was replaced with a N-substituted piperidinyloxy moiety. were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms. The effect of ring size, positional isomerism, and fluorine substitution on antibacterial activity was examined. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1829 / 1832

页数：4

共 50 条

[1] Novel piperidinyloxy-oxazolidinone antimicrobial agents: Effects of position, fluorine substitution, and ring-size on in vitro antimicrobial activity
Boggs, CM
Weidner-Wells, MA
Nelson, EA
Goldschmidt, R
Foleno, B
Bush, K
Hlasta, DJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U554 - U554
[2] Novel piperidinyloxy oxazolidinone antibacterial agents.: Diversification of the N-substituent
Weidner-Wells, MA
Boggs, CM
Foleno, BD
Melton, J
Bush, K
Goldschmidt, RM
Hlasta, DJ
BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (07) : 2345 - 2351
[3] Synthesis of novel oxazolidinone antimicrobial agents
Ebner, David C.
Culhane, Jeffrey C.
Winkelman, Tyler N.
Haustein, Mitchell D.
Ditty, Jayna L.
Ippoliti, J. Thomas
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (05) : 2651 - 2656
[4] Synthesis of a novel oxazolidinone antimicrobial
Luyen Nguyen
Ippoliti, J. Thomas
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
[5] Synthesis of a novel oxazolidinone antimicrobial agent
Ogorek, Tyler
Ippoliti, Joseph
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
[6] Synthesis of novel oxazolidinone antimicrobial compounds
Winkelman, Tyler N.
Ippoliti, J. Thomas
Ditty, Jayna L.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
[7] In vitro activity of linezolid and eperezolid, two novel oxazolidinone antimicrobial agents, against anaerobic bacteria
Yagi, BH
Zurenko, GE
ANAEROBE, 1997, 3 (05) : 301 - 306
[8] In vitro activities of new oxazolidinone antimicrobial agents against enterococci
Eliopoulos, GM
Wennersten, CB
Gold, HS
Moellering, RC
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (07) : 1745 - 1747
[9] Design and synthesis of novel thioether-linked carbapenem-oxazolidinone hybrids as potential antimicrobial agents
Wang, Jianwei
Huang, Juan
Wu, Yong
Hai, Li
Wang, Guangming
LETTERS IN ORGANIC CHEMISTRY, 2008, 5 (05) : 336 - 341
[10] Recent developments in the identification of novel oxazolidinone antibacterial agents
Renslo, Adam R.
Luehr, Gary W.
Gordeev, Mikhail F.
BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (12) : 4227 - 4240

← 1 2 3 4 5 →