Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells

被引：141
|
作者：
O'Loughlin, EV
Robins-Browne, RM
机构：
[1] Royal Alexandra Hosp Children, Dept Gastroenterol, Westmead, NSW 2124, Australia
[2] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia
[3] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia
来源：
MICROBES AND INFECTION | 2001年 / 3卷 / 06期
关键词：
Shiga toxin; pathogenesis; haemolytic uremic syndrome;
D O I：
10.1016/S1286-4579(01)01405-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Shigella dysenteriae and Shiga-toxin-producing Escherichia call (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：493 / 507
页数：15
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