Effects of circadian misalignment on cognition in chronic shift workers

被引:74
|
作者
Chellappa, Sarah L. [1 ,2 ,3 ]
Morris, Christopher J. [1 ,2 ,3 ]
Scheer, Frank A. J. L. [1 ,2 ,3 ]
机构
[1] Brigham & Womens Hosp, Dept Med, Med Chronobiol Program, Div Sleep & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Neurol, Med Chronobiol Program, Div Sleep & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA
[3] Harvard Med Sch, Div Sleep Med, Dept Med, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
SLEEP RESTRICTION; PERFORMANCE; WAKEFULNESS; FATIGUE; TIME; ACCURACY; RHYTHMS; SAFETY; PHASE; SPEED;
D O I
10.1038/s41598-018-36762-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Shift work is associated with increased human operational errors, presumably due to the circadian timing system that inhibits optimal cognitive function during the night. Circadian misalignment, which is the misalignment between the circadian pacemaker and behavioral/environmental cycles, impairs cognitive performance in non-shift workers. However, it remains uncertain whether the adverse cognitive consequences of circadian misalignment are also observed in chronic shift workers. Thus, we investigated the effects of circadian misalignment on cognitive performance in chronic shift workers. Using a randomized, cross-over design that simulated day shift work (circadian alignment) and night shift work (circadian misalignment), we show that circadian misalignment increases cognitive vulnerability on sustained attention, information processing and visual-motor performance, particularly after more than 10 hours of scheduled wakefulness. Furthermore, their increased levels of subjective sleepiness and their decreased sleep efficiency were significantly associated with impaired sustained attention and visual-motor performance. Our data suggest that circadian misalignment dramatically deteriorates cognitive performance in chronic shift workers under circadian misalignment. This increased cognitive vulnerability may have important safety consequences, given the increasing number of nighttime jobs that crucially rely on the availability of cognitive resources.
引用
收藏
页数:9
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