Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

被引：596
|
作者：
Cingolani, Lorenzo A. [1 ]
Goda, Yukiko [1 ]
机构：
[1] UCL, Dept Neurobiol Physiol & Pharmacol, London WC1E 6BT, England
来源：
NATURE REVIEWS NEUROSCIENCE | 2008年 / 9卷 / 05期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1038/nrn2373
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Synapse regulation exploits the capacity of actin to function as a stable structural component or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological changes at the synapse, the emerging picture points to an active contribution of actin to the modulation of the efficacy of pre- and postsynaptic terminals. Moreover, by engaging distinct pools of actin and divergent signalling pathways, actin-dependent morphological plasticity could be uncoupled from modulation of synaptic strength. The aim of this Review is to highlight some of the recent progress in elucidating the role of the actin cytoskeleton in synaptic function.
引用
收藏
页码：344 / 356
页数：13
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