Hepatitis A Epidemiology, Natural History, Unusual Clinical Manifestations, and Prevention

被引：53

作者：

Abutaleb, Ameer ^{[1
,2
]}

Kottilil, Shyam ^{[1
]}

机构：

[1] Univ Maryland, Inst Human Virol, Div Clin Care & Res, 725 West Lombard St Suite, Baltimore, MD 21201 USA

[2] Univ Maryland, Dept Med, Div Gastroenterol & Hepatol, 22 South Greene St,N3W156, Baltimore, MD 21201 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2020年 / 49卷 / 02期

关键词：

Hepatitis A virus; Hepatitis A vaccine; Acute liver failure; Hepatitis A outbreak; Hepatitis A prevention; IMMUNOGLOBULIN-M ANTIBODIES; INFECTIOUS-HEPATITIS; VIRUS-REPLICATION; VIRAL-HEPATITIS; IMMUNE GLOBULIN; VACCINE; LIVER; SERUM; IMMUNOGENICITY; INTERFERON;

D O I：

10.1016/j.gtc.2020.01.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis A virus (HAV) is a positive-strand RNA virus that is transmitted feco-orally through person-to-person contact. Outbreaks are often linked to poor sanitation, overcrowding, or food and water contamination. Infection is often asymptomatic in children, but adults present with jaundice, abdominal pain, hepatitis, and hyperbilirubinemia. Diagnosis is through detection of immunoglobulin M antibodies against HAV, and treatment is supportive. Vaccination is the mainstay of prevention and should be given before exposure whenever possible.

引用

页码：191 / +

页数：10

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