Indinavir-induced nephrolithiasis three and one-half years after cessation of indinavir therapy

被引：5
|
作者：
Huynh, Julie [1 ,2 ]
Hever, Aviv [3 ]
Tom, Thomas [2 ]
Sim, John J. [1 ]
机构：
[1] Kaiser Permanente, Los Angeles Med Ctr, Div Nephrol & Hypertens, Los Angeles, CA 90027 USA
[2] Kaiser Permanente, Los Angeles Med Ctr, Dept Internal Med, Los Angeles, CA 90027 USA
[3] Kaiser Permanente, Los Angeles Med Ctr, Dept Renal Pathol, Los Angeles, CA 90027 USA
来源：
INTERNATIONAL UROLOGY AND NEPHROLOGY | 2011年 / 43卷 / 02期
关键词：
UROLITHIASIS;
D O I：
10.1007/s11255-010-9751-6
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Nephrolithiasis is a known side effect of indinavir sulfate, a protease inhibitor used in the treatment of human immunodeficiency virus (HIV). The duration of its side effects, however, has not been well defined. We present a case where a patient presented with symptomatic indinavir-induced nephrolithiasis 3.5 years after discontinuing indinavir. We use this case to illustrate the pathophysiology of indinavir stones and hypothesize how they can occur years after discontinuation by discussing the pharmacokinetics of the drug.
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页码：571 / 573
页数：3
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